Abstract
The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adipose Tissue / metabolism
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Adiposity / physiology
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Animals
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Central Nervous System / physiology*
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Diabetes Mellitus / metabolism
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Glucose / metabolism*
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Homeostasis / physiology
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Humans
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Insulin / physiology
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Janus Kinases / metabolism
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Leptin / physiology*
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Nerve Net / physiology
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Nutritional Physiological Phenomena
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Obesity / metabolism
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Phosphatidylinositol 3-Kinases / metabolism
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Signal Transduction / physiology
Substances
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Insulin
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Leptin
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Phosphatidylinositol 3-Kinases
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Janus Kinases
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Glucose