The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels

Cell Calcium. 2011 Aug;50(2):157-67. doi: 10.1016/j.ceca.2011.03.011. Epub 2011 May 6.

Abstract

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acids / metabolism
  • Animals
  • Calcium / metabolism*
  • Calcium Channels / genetics
  • Calcium Channels / metabolism*
  • Cell Membrane / metabolism
  • Endosomes / metabolism*
  • Humans
  • Ion Channel Gating
  • Lysosomes / metabolism*
  • NADP / analogs & derivatives*
  • NADP / metabolism
  • Potassium Channels, Voltage-Gated / metabolism
  • Sodium Channels / metabolism
  • Sodium-Calcium Exchanger / metabolism

Substances

  • Acids
  • Calcium Channels
  • Potassium Channels, Voltage-Gated
  • Sodium Channels
  • Sodium-Calcium Exchanger
  • NADP
  • NAADP
  • Calcium