Abstract
Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
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Administration, Oral
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Animals
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Anticonvulsants / pharmacology
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Binding, Competitive / drug effects
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Crystallography, X-Ray
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Mice
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Molecular Structure
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Quinazolinones / chemical synthesis*
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Quinazolinones / chemistry
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Quinazolinones / pharmacology
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Rats
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Receptors, AMPA / antagonists & inhibitors*
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis*
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Sulfonamides / chemistry
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Sulfonamides / pharmacology
Substances
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Anticonvulsants
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Quinazolinones
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Receptors, AMPA
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Sulfonamides