Abstract
We report the use of antimicrobial hemolymph proteins from the model host Galleria mellonella as an inhibitor for various Listeria strains, providing a novel source for antilisterial therapeutics. We also have shown that specific virulence-associated genes known to mediate antimicrobial resistance of Listeria in mammalian models indicated a similar function in Galleria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimicrobial Cationic Peptides / genetics
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Antimicrobial Cationic Peptides / pharmacology*
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Gene Deletion
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Hemolymph / chemistry*
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Insect Proteins / genetics
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Insect Proteins / pharmacology*
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Lepidoptera
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Listeria / drug effects*
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Listeria / growth & development
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Survival Analysis
Substances
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Antimicrobial Cationic Peptides
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Insect Proteins