Abstract
Seven novel 4β-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemical synthesis
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / pharmacology
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Drug Resistance, Multiple / drug effects
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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K562 Cells
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KB Cells
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Molecular Structure
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Podophyllotoxin* / analogs & derivatives
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Podophyllotoxin* / chemical synthesis
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Podophyllotoxin* / chemistry
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Podophyllotoxin* / pharmacology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Podophyllotoxin