Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex

J Neuroimmunol. 2011 Jun;235(1-2):77-83. doi: 10.1016/j.jneuroim.2011.02.011. Epub 2011 May 2.

Abstract

Susceptibility to sporadic inclusion body myositis (sIBM) in Caucasians has been consistently associated with alleles of the major histocompatibility complex (MHC) 8.1 ancestral haplotype (AH) (defined by HLA-B*0801 and HLA-DRB1*0301). In this study recombination mapping was utilised to further refine the known 8.1AH susceptibility region near HLA-DRB1*0301. Caucasian sIBM patients carrying part of the 8.1AH were genotyped for a selection of 8.1AH-haplotypic polymorphisms. A common 8.1AH-specific susceptibility region was defined, spanning 172 kb and encompassing three genes--HLA-DRB3, HLA-DRA and BTNL2. It is thus likely that 8.1AH-derived susceptibility to sIBM originates from at least one of these genes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Cell Line
  • Chromosome Mapping / methods*
  • Cohort Studies
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Major Histocompatibility Complex / genetics*
  • Myositis, Inclusion Body / epidemiology
  • Myositis, Inclusion Body / genetics*
  • Recombination, Genetic / immunology*

Substances

  • Genetic Markers