Abstract
Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascus infections are discussed.
MeSH terms
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Adult
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Antifungal Agents / administration & dosage
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Ascomycota / classification
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Ascomycota / genetics
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Ascomycota / isolation & purification*
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Caspofungin
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Cystic Fibrosis / complications*
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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Echinocandins / administration & dosage
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Fatal Outcome
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Fungemia / diagnosis*
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Fungemia / microbiology
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Fungemia / mortality
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Fungemia / pathology
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Heart Transplantation / adverse effects*
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Histocytochemistry
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Humans
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Immunocompromised Host
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Lipopeptides
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Lung Transplantation / adverse effects*
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Male
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Microscopy
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Molecular Sequence Data
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Mycoses / diagnosis*
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Mycoses / microbiology
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Mycoses / mortality
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Mycoses / pathology
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Pleura / pathology
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Pyrimidines / administration & dosage
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Radiography, Thoracic
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Sequence Analysis, DNA
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Tomography, X-Ray Computed
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Triazoles / administration & dosage
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Voriconazole
Substances
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Antifungal Agents
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DNA, Fungal
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Echinocandins
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Lipopeptides
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Pyrimidines
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Triazoles
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Caspofungin
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Voriconazole