Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells

Angew Chem Int Ed Engl. 2011 Jun 14;50(25):5734-6. doi: 10.1002/anie.201101042. Epub 2011 May 5.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cellular Reprogramming*
  • Dasatinib
  • Doxycycline / pharmacology
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • High-Throughput Screening Assays
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / metabolism
  • Mice
  • Protein Kinase Inhibitors / chemistry*
  • Protein Kinase Inhibitors / pharmacology
  • Pyrimidines / chemistry
  • Pyrimidines / pharmacology
  • SOXB1 Transcription Factors / genetics
  • SOXB1 Transcription Factors / metabolism*
  • Thiazoles / chemistry
  • Thiazoles / pharmacology
  • Transforming Growth Factor beta / antagonists & inhibitors
  • Transforming Growth Factor beta / metabolism
  • src-Family Kinases / antagonists & inhibitors*
  • src-Family Kinases / genetics
  • src-Family Kinases / metabolism

Substances

  • Protein Kinase Inhibitors
  • Pyrimidines
  • SOXB1 Transcription Factors
  • Sox2 protein, mouse
  • Thiazoles
  • Transforming Growth Factor beta
  • src-Family Kinases
  • Doxycycline
  • Dasatinib