Broken silence restored--remodeling primes for deacetylation at replication forks

Zuzana Jasencakova; Anja Groth

doi:10.1016/j.molcel.2011.04.007

Broken silence restored--remodeling primes for deacetylation at replication forks

Mol Cell. 2011 May 6;42(3):267-9. doi: 10.1016/j.molcel.2011.04.007.

Authors

Zuzana Jasencakova¹, Anja Groth

Affiliation

¹ Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.

PMID: 21549303
DOI: 10.1016/j.molcel.2011.04.007

Abstract

Faithful propagation of chromatin structures requires assimilation of new histones to the modification profile of individual loci. In this issue of Molecular Cell, Rowbotham and colleagues identify a remodeler, SMARCAD1, acting at replication sites to facilitate histone deacetylation and restoration of silencing.

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