Camlog tube-in-tube implants were introduced several years ago. This multicenter retrospective analysis evaluated the success rate of Root-Line and Screw-Line tube-in-tube implants in daily use. A total of 201 implants were placed in 96 patients with different indications and implantation procedures. Implants were analyzed retrospectively after a functional loading period of 12 to 78 months. At the end of the observation period, all but 1 implant fulfilled the success criteria, resulting in an implant survival rate of 99.5%. Individual case analysis of implants in special indications, such as immediate loading, short implants, and tilted implants, did not indicate any increased risk of implant failure.