Metabolomics, pathway regulation, and pathway discovery

J Biol Chem. 2011 Jul 8;286(27):23631-5. doi: 10.1074/jbc.R110.171405. Epub 2011 May 12.

Abstract

Metabolomics is a data-based research strategy, the aims of which are to identify biomarker pictures of metabolic systems and metabolic perturbations and to formulate hypotheses to be tested. It involves the assay by mass spectrometry or NMR of many metabolites present in the biological system investigated. In this minireview, we outline studies in which metabolomics led to useful biomarkers of metabolic processes. We also illustrate how the discovery potential of metabolomics is enhanced by associating it with stable isotopic techniques.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism*
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry / methods
  • Metabolome / physiology*
  • Metabolomics / methods*
  • Metabolomics / trends

Substances

  • Biomarkers