This paper reported a case with hereditary enamel maldevelopment. A 18-year-old female sought for dental treatment due to all teeth with yellowish-brown, anterior open bite and occluso-cervical strips of smooth enamel alternating with pitted, wrinkled, or exposed dentin, and vertical dimension decreased. The same disease also happened in her other family members. Her teeth lesions were preliminarily treated, and further treatment plan was provided.