Abstract
Bacteremia contributes to morbidity of HIV-infected children. In a randomized controlled trial evaluating trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis, 47 bacteremias were detected. The incidence rate of bacteremia increased in the first 3 months after starting combination antiretroviral therapy (cART), but decreased by 74% once children were established on cART for more than 3 months. Children should be prioritized for early cART.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-HIV Agents / administration & dosage
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Antibiotic Prophylaxis / methods*
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Antiretroviral Therapy, Highly Active / methods
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Bacteremia / epidemiology*
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Bacteremia / prevention & control*
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Child
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Child, Preschool
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy
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Humans
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Incidence
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Infant
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Male
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South Africa / epidemiology
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Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage*
Substances
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Anti-HIV Agents
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Trimethoprim, Sulfamethoxazole Drug Combination