Stereoselective synthesis of fluorinated 1,3-cis-diaminocyclopentanes

Morgane Pasco; Roba Moumné; Thomas Lecourt; Laurent Micouin

doi:10.1021/jo2001512

Stereoselective synthesis of fluorinated 1,3-cis-diaminocyclopentanes

J Org Chem. 2011 Jun 17;76(12):5137-42. doi: 10.1021/jo2001512. Epub 2011 May 24.

Authors

Morgane Pasco¹, Roba Moumné, Thomas Lecourt, Laurent Micouin

Affiliation

¹ UMR8638, CNRS-Paris Descartes University, Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, 4 av. de l'Observatoire, 75006 Paris, France.

PMID: 21574598
DOI: 10.1021/jo2001512

Abstract

Several fluorinated 1,3-diaminocyclopentanes, previously reported to be useful RNA structural probes, can be prepared in a diastereoselective manner from a single bicyclic hydrazine precursor, in 3 to 9 steps.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Cyclopentanes / chemical synthesis*
Halogenation
Molecular Structure
Stereoisomerism

Substances

Cyclopentanes