In the title compound, C(16)H(8)Cl(2)F(2)N(4)O(2)S, the thia-diazole ring makes dihedral angles of 24.94 (14) and 48.11 (14)°, respectively, with the dichloro- and difluoro-substituted benzene rings. An intra-molecular N-H⋯O hydrogen bond results in the formation of a planar (mean deviation 0.0091 Å) six-membered ring. In the crystal structure, mol-ecules form centrosymmetric dimers through pairs of inter-molecular N-H⋯O hydrogen bonds.