Synthesis of 11C-labeled (+-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imin e [(+-)-[11C]MK801]

D O Kiesewetter; R D Finn; K C Rice; J A Monn

doi:10.1016/0883-2889(90)90098-2

Synthesis of 11C-labeled (+-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imin e [(+-)-[11C]MK801]

Int J Rad Appl Instrum A. 1990;41(2):139-42. doi: 10.1016/0883-2889(90)90098-2.

Authors

D O Kiesewetter¹, R D Finn, K C Rice, J A Monn

Affiliation

¹ Department of Nuclear Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.

PMID: 2158943
DOI: 10.1016/0883-2889(90)90098-2

Abstract

The synthesis of C5 labeled (+-)-5-[11C]methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten- 5,10-imine [(+-)-[11C]MK801] has been accomplished via alkylation of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine-N-t- butylformamidine [(+-)-5-des-methyl MK801 formamidine). The 11C labeling is accomplished by reaction of the anion of (+-)-5-des-methyl MK801 formamidine, generated with s-butyllithium, and [11C]methyl iodide.

MeSH terms

Carbon Radioisotopes
Dibenzocycloheptenes / chemical synthesis*
Dizocilpine Maleate
Isotope Labeling / methods*

Substances

Carbon Radioisotopes
Dibenzocycloheptenes
Dizocilpine Maleate