Microsomal activation and increased production of 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide (m-AMSA)-dependent, topoisomerase-associated DNA lesions in nuclei from human HL-60 leukemia cells

Biochem Pharmacol. 1990 May 1;39(9):1481-4. doi: 10.1016/0006-2952(90)90430-s.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amsacrine / pharmacology*
  • Cell Nucleus
  • DNA Damage*
  • DNA Topoisomerases, Type II / metabolism*
  • DNA, Neoplasm / drug effects*
  • Humans
  • Leukemia, Promyelocytic, Acute / metabolism*
  • Microsomes / metabolism*
  • Tumor Cells, Cultured

Substances

  • DNA, Neoplasm
  • Amsacrine
  • DNA Topoisomerases, Type II