CFTR three-dimensional structure

Robert C Ford; James Birtley; Mark F Rosenberg; Liang Zhang

doi:10.1007/978-1-61779-117-8_22

CFTR three-dimensional structure

Methods Mol Biol. 2011:741:329-46. doi: 10.1007/978-1-61779-117-8_22.

Authors

Robert C Ford¹, James Birtley, Mark F Rosenberg, Liang Zhang

Affiliation

¹ Faculty of Life Sciences, Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester, UK. [email protected]

PMID: 21594795
DOI: 10.1007/978-1-61779-117-8_22

Abstract

CFTR is a member of the ATP-binding cassette family of membrane proteins. This is one of the best characterised membrane protein families in terms of structure and function. CFTR operates as an ion channel, unlike nearly all other family members which are active transporters. Here, we discuss methods that have allowed such data to be obtained for CFTR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cryoelectron Microscopy
Crystallography, X-Ray
Cystic Fibrosis Transmembrane Conductance Regulator / chemistry*
Detergents / chemistry
Humans
Imaging, Three-Dimensional
Microscopy, Electron, Transmission
Protein Structure, Tertiary
Solubility

Substances

Detergents
Cystic Fibrosis Transmembrane Conductance Regulator