Allogeneic hematopoietic stem cell transplantation for advanced extranodal natural killer/T-cell lymphoma, nasal type

Leuk Lymphoma. 2011 Jul;52(7):1255-61. doi: 10.3109/10428194.2011.572322. Epub 2011 May 23.

Abstract

The prognosis for patients with advanced or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKL) is extremely poor. Thus, allogeneic stem cell transplantation (allo-HSCT) should be considered for this disease. However, reports of allo-HSCT for ENKL are limited because of the rarity of the disease. Here, we describe the clinical course of 12 cases of advanced and refractory ENKL treated with allo-HSCT, including five cases with cord blood transplant. With a median follow-up of 13 months (range, 1-168 months), seven patients are alive in remission, five have died, and one treatment-related death occurred. All patients with disease progression at transplant died of disease progression, whereas seven of eight patients with a complete or partial response are long-term survivors. Allo-HSCT is a feasible and promising consolidation therapy for advanced and relapsed ENKL. The disease status before allo-HSCT is well associated with general outcome, and thus induction treatment is very important for this disease.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / pathology
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Lymphoma, Extranodal NK-T-Cell / mortality
  • Lymphoma, Extranodal NK-T-Cell / pathology*
  • Lymphoma, Extranodal NK-T-Cell / therapy*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Survival Analysis
  • Transplantation, Homologous
  • Treatment Outcome
  • Young Adult