Wnt signaling through T-cell factor phosphorylation

Cell Res. 2011 Jul;21(7):1002-12. doi: 10.1038/cr.2011.86. Epub 2011 May 24.

Abstract

Embryonic signaling pathways often lead to a switch from default repression to transcriptional activation of target genes. A major consequence of Wnt signaling is stabilization of β-catenin, which associates with T-cell factors (TCFs) and 'converts' them from repressors into transcriptional activators. The molecular mechanisms responsible for this conversion remain poorly understood. Several studies have reported on the regulation of TCF by phosphorylation, yet its physiological significance has been unclear: in some cases it appears to promote target gene activation, in others Wnt-dependent transcription is inhibited. This review focuses on recent progress in the understanding of context-dependent post-translational regulation of TCF function by Wnt signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental
  • Humans
  • Phosphorylation
  • Signal Transduction
  • TCF Transcription Factors / genetics
  • TCF Transcription Factors / metabolism*
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism*
  • beta Catenin / genetics
  • beta Catenin / metabolism

Substances

  • TCF Transcription Factors
  • Wnt Proteins
  • beta Catenin