Aphallia in an adult male with 46, XY karyotype

Int J Urol. 2011 Jul;18(7):540-2. doi: 10.1111/j.1442-2042.2011.02785.x. Epub 2011 May 25.

Abstract

Aphallia is a rare urogenital anomaly with an estimated incidence of 1 in 10-30 million. We report a case of aphallia in a male, who had two well-developed testicles, but lacked a penis. Digital rectal examination revealed the urethral meatus was opening to the anterior wall of the rectum posterior to the sphincter. Magnetic resonance imaging showed complete absence of penile development with normal testis and scrotum, as well as the urethra running posterior to the prostatic apex and corpus spongiosum in sagittal and coronal T2-weighted images. Chromosome karyotype confirmed 46,XY, and the polymerase chain reaction method tested no azoospermic factor (AZF) or sex-determining region Y (SRY) gene deletion. Taking into account the physical and psychosocial conditions, seeking a female without sexual desire as his wife was recommended.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Genital Diseases, Male / genetics*
  • Genital Diseases, Male / pathology*
  • Gonadal Dysgenesis, 46,XY / genetics*
  • Gonadal Dysgenesis, 46,XY / pathology*
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Penis / abnormalities
  • Penis / pathology
  • Testis / anatomy & histology
  • Testis / growth & development*
  • Urethra / abnormalities

Supplementary concepts

  • Penis agenesis