Abstract
The total synthesis of bryostatin 9 was accomplished using a uniquely step-economical and convergent Prins-driven macrocyclization strategy. At 25 linear and 42 total steps, this is currently the most concise and convergent synthesis of a potent bryostatin.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Bryostatins / chemical synthesis*
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Bryostatins / chemistry
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Bryostatins / metabolism
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Cyclization
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Protein Kinase C / metabolism
Substances
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Bryostatins
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Protein Kinase C