Abstract
Myceliophthora thermophila is a thermophilic mould widely found in the environment but rarely responsible for human infections. We describe a case of invasive Myceliophthora thermophila infection mimicking invasive aspergillosis in a neutropenic patient with haematological malignancy. Cross-reactivity with Aspergillus galactomannan assay (GM) was demonstrated by repeated positive results and confirmed by cross-reaction between the fungal isolate and the GM assay. The patient was successfully treated with voriconazole. Potential GM cross-reactivity must be considered in future studies including patients categorized as having probable invasive aspergillosis using the GM as the only mycological criterion.
MeSH terms
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Antifungal Agents / therapeutic use
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Antigens, Fungal / blood*
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Aspergillosis / immunology
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Aspergillosis / microbiology
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Aspergillus / immunology
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Base Sequence
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Cross Reactions
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Diagnosis, Differential
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Galactose / analogs & derivatives
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Hematologic Neoplasms / complications
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Hematologic Neoplasms / drug therapy
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Humans
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Male
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Mannans / blood*
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Middle Aged
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Molecular Sequence Data
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Mycoses / complications
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Mycoses / diagnosis*
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Mycoses / drug therapy
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Mycoses / microbiology
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Neutropenia
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Pyrimidines / therapeutic use
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Sensitivity and Specificity
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Sordariales / cytology
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Sordariales / drug effects
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Sordariales / immunology*
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Sordariales / isolation & purification
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Spores, Fungal
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Triazoles / therapeutic use
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Voriconazole
Substances
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Antifungal Agents
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Antigens, Fungal
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Mannans
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Pyrimidines
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Triazoles
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galactomannan
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Voriconazole
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Galactose
Associated data
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GENBANK/HQ676489
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GENBANK/HQ676490
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GENBANK/HQ724320
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GENBANK/HQ724321