Abstract
We show that Schmidt-Ruppin D pp60v-src kinase activity is reduced by a mutation previously shown to be associated with Schmidt-Ruppin A pp60v-src temperature sensitivity and that its reduced transforming activity is associated with a conformational change in the SH3 region. The evolutionary relationship of seven v-src strains was studied by using parsimony analysis.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Avian Leukosis Virus / classification
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Avian Leukosis Virus / genetics*
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Base Sequence
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Biological Evolution
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Cloning, Molecular
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Molecular Sequence Data
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Oncogene Protein pp60(v-src) / genetics*
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Peptide Mapping
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Polymorphism, Genetic
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Protein-Tyrosine Kinases / genetics*
Substances
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Protein-Tyrosine Kinases
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Oncogene Protein pp60(v-src)