Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy

Radiother Oncol. 2011 May;99(2):231-4. doi: 10.1016/j.radonc.2011.05.007. Epub 2011 May 26.

Abstract

Many genes have been associated with radiotherapy toxicity, but most have only been found in a single study. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / genetics
  • Breast Neoplasms / radiotherapy*
  • Breast Neoplasms / surgery
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / radiation effects
  • Chi-Square Distribution
  • DNA Ligase ATP
  • DNA Ligases / genetics*
  • DNA Ligases / radiation effects*
  • DNA Repair / genetics*
  • Female
  • Genotype
  • Haplotypes
  • Humans
  • Japan
  • Linear Models
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / radiation effects
  • Phenotype
  • Poly-ADP-Ribose Binding Proteins
  • Polymorphism, Single Nucleotide*
  • Principal Component Analysis
  • Radiation Injuries / genetics*
  • Radiotherapy / adverse effects*
  • Radiotherapy Dosage
  • Securin
  • Skin / radiation effects*
  • Statistics, Nonparametric
  • Xenopus Proteins

Substances

  • Cell Cycle Proteins
  • Neoplasm Proteins
  • Poly-ADP-Ribose Binding Proteins
  • Securin
  • Xenopus Proteins
  • rad9 protein
  • DNA Ligases
  • DNA Ligase ATP
  • DNA ligase III alpha protein, Xenopus
  • LIG3 protein, human