Identification of the new HLA-A*31:48 allele in an Italian patient

Tissue Antigens. 2011 Oct;78(4):286-7. doi: 10.1111/j.1399-0039.2011.01712.x. Epub 2011 May 29.

Abstract

Human leukocyte antigen (HLA) class I sequence-based typing (SBT) for hematopoietic unrelated donor searching in an Italian Caucasian patient showed the presence of a novel HLA-A allele defined as A*31:48. HLA-A*31:48 has one nucleotide change from A*31:01:02 at nt 727 from C to T, resulting in an amino acid change at codon 219 of exon 4 from Arg to Trp.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alleles*
  • Amino Acid Substitution*
  • Anemia, Aplastic / genetics
  • Anemia, Aplastic / therapy
  • Female
  • HLA-A Antigens / genetics*
  • Humans
  • Mutation, Missense*

Substances

  • HLA-A Antigens