Role of guanylyl cyclase modulation in mouse cone phototransduction

J Neurosci. 2011 Jun 1;31(22):7991-8000. doi: 10.1523/JNEUROSCI.6650-10.2011.

Abstract

A negative phototransduction feedback in rods and cones is critical for the timely termination of their light responses and for extending their function to a wide range of light intensities. The calcium feedback mechanisms that modulate phototransduction in rods have been studied extensively. However, the corresponding modulation mechanisms that enable cones to terminate rapidly their light responses and to adapt in bright light, properties critical for our daytime vision, are still not understood. In cones, calcium feedback to guanylyl cyclase is potentially a key step in phototransduction modulation. The guanylyl cyclase activity is modulated by the calcium-binding guanylyl cyclase activating proteins (GCAP1 and GCAP2). Here, we used single-cell and transretinal recordings from mouse to determine how GCAPs modulate dark-adapted responses as well as light adaptation in mammalian cones. Deletion of GCAPs increased threefold the amplitude and dramatically prolonged the light responses in dark-adapted mouse cones. It also reduced the operating range of mouse cones in background illumination and severely impaired their light adaptation. Thus, GCAPs exert powerful modulation on the mammalian cone phototransduction cascade and play an important role in setting the functional properties of cones in darkness and during light adaptation. Surprisingly, despite their better adaptation capacity and wider calcium dynamic range, mammalian cones were modulated by GCAPs to a lesser extent than mammalian rods. We conclude that a disparity in the strength of GCAP modulation cannot explain the differences in the dark-adapted properties or in the operating ranges of mammalian rods and cones.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Adaptation, Ocular / physiology
  • Animals
  • Egtazic Acid / analogs & derivatives
  • Egtazic Acid / pharmacology
  • Electroretinography / methods
  • Female
  • Guanylate Cyclase / physiology*
  • Guanylate Cyclase-Activating Proteins / genetics*
  • Guanylate Cyclase-Activating Proteins / metabolism
  • In Vitro Techniques
  • Male
  • Mice
  • Mice, Knockout
  • Photic Stimulation
  • Retinal Cone Photoreceptor Cells / metabolism
  • Retinal Cone Photoreceptor Cells / physiology*
  • Retinal Rod Photoreceptor Cells / physiology
  • Vision, Ocular / drug effects
  • Vision, Ocular / physiology*

Substances

  • Guanylate Cyclase-Activating Proteins
  • Egtazic Acid
  • Guanylate Cyclase
  • 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid