Complete regression of retinoblastoma following intra-arterial chemotherapy

J Pediatr Ophthalmol Strabismus. 2011 Jun 7:48 Online:e23-5. doi: 10.3928/01913913-20110531-02.

Abstract

A 22-month-old girl with Group C unilateral retinoblastoma demonstrated dramatic tumor regression after two infusions of 5 mg of intra-arterial melphalan as primary therapy. Complete tumor control without recurrence was noted at 1 year. Retinal and choroidal perfusion was intact and the electroretinogram improved following therapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Electroretinography
  • Female
  • Fluorescein Angiography
  • Humans
  • Infant
  • Infusions, Intra-Arterial
  • Melphalan / administration & dosage
  • Melphalan / therapeutic use*
  • Ophthalmic Artery
  • Retina / physiopathology
  • Retinal Neoplasms / diagnostic imaging
  • Retinal Neoplasms / drug therapy*
  • Retinal Neoplasms / pathology
  • Retinoblastoma / diagnostic imaging
  • Retinoblastoma / drug therapy*
  • Retinoblastoma / pathology
  • Ultrasonography

Substances

  • Antineoplastic Agents, Alkylating
  • Melphalan