Custom made bioceramic implants in complex and large cranial reconstruction: a two-year follow-up

J Craniomaxillofac Surg. 2012 Apr;40(3):e65-70. doi: 10.1016/j.jcms.2011.04.014. Epub 2011 Jun 2.

Abstract

Introduction: Large cranial defects still represent a challenge in neurosurgery. Currently different biomaterials are available for cranial reconstruction including titanium, acrylic mesh and different types of calcium phosphate-based bone grafts. The goal of surgery is a perfect fit of the implant without infection and absorption, and a good aesthetic result. This paper describes a surgical method for cranioplasty, using a customised porous hydroxyapatite (HA) prosthesis.

Materials and methods: Sixty patients treated surgically with a customised porous-HA prosthesis for large cranial defects, were followed retrospectively. A two-year follow-up was carried out with periodic visits and CT scans. Safety (the incidence of adverse events and fractures of the implant) and clinical performance (biological and cosmetic results) were evaluated.

Results: Fifty one patients were followed-up, no rejection occurred and only one case of infection was recorded. Five patients had minor surgery-related complications, and no spontaneous implant fractures or mobilisation were reported. Three patients exhibited implant fractures as a result of trauma and all healed spontaneously. All patients showed a satisfactory clinical outcome with good cosmetic appearance in the early postoperative period and after a long-term follow-up.

Conclusions: Cranioplasty performed with a customised porous-HA prosthesis gave a positive outcome, showing it to be an appropriate technique for use in large and complex cranial reconstruction.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biocompatible Materials / chemistry*
  • Ceramics / chemistry*
  • Computer-Aided Design
  • Craniotomy / methods*
  • Durapatite / chemistry*
  • Equipment Safety
  • Esthetics
  • Follow-Up Studies
  • Frontal Bone / surgery
  • Humans
  • Hydroxyapatites / chemistry
  • Imaging, Three-Dimensional / methods
  • Middle Aged
  • Osseointegration / physiology
  • Parietal Bone / surgery
  • Patient Satisfaction
  • Plastic Surgery Procedures / instrumentation*
  • Plastic Surgery Procedures / methods
  • Postoperative Complications
  • Prosthesis Design*
  • Prosthesis-Related Infections / etiology
  • Retrospective Studies
  • Temporal Bone / surgery
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome
  • Young Adult

Substances

  • Biocompatible Materials
  • Hydroxyapatites
  • hydroxyapatite-tricalciumphosphate composite
  • Durapatite