Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4

G Rajeshwar Reddy; T Ram Reddy; Suju C Joseph; K Sateesh Reddy; L Srinivasula Reddy; P Mahesh Kumar; G Rama Krishna; C Malla Reddy; D Rambabu; Ravikumar Kapavarapu; Chandana Lakshmi; Teja Meda; K Krishna Priya; Kishore V L Parsa; Manojit Pal

doi:10.1039/c1cc12321a

Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4

Chem Commun (Camb). 2011 Jul 21;47(27):7779-81. doi: 10.1039/c1cc12321a. Epub 2011 Jun 3.

Authors

G Rajeshwar Reddy¹, T Ram Reddy, Suju C Joseph, K Sateesh Reddy, L Srinivasula Reddy, P Mahesh Kumar, G Rama Krishna, C Malla Reddy, D Rambabu, Ravikumar Kapavarapu, Chandana Lakshmi, Teja Meda, K Krishna Priya, Kishore V L Parsa, Manojit Pal

Affiliation

¹ Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500 049, India.

PMID: 21643571
DOI: 10.1039/c1cc12321a

Abstract

A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.

MeSH terms

Catalysis
Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism*
HEK293 Cells
Humans
Models, Molecular
Palladium / chemistry*
Phosphodiesterase 4 Inhibitors / chemical synthesis*
Phosphodiesterase 4 Inhibitors / pharmacology*
Pyrroles / chemical synthesis*
Pyrroles / pharmacology*

Substances

Phosphodiesterase 4 Inhibitors
Pyrroles
Palladium
Cyclic Nucleotide Phosphodiesterases, Type 4