Abstract
Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antibodies, Neutralizing / blood*
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Cross Reactions
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Evolution, Molecular
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Genes, env
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Genetic Variation*
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HIV Antibodies / blood*
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HIV Infections / immunology
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HIV Infections / virology*
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HIV-1 / genetics*
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HIV-1 / immunology*
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HIV-1 / physiology
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Humans
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Molecular Sequence Data
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Sequence Analysis, Protein
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env Gene Products, Human Immunodeficiency Virus / chemistry
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env Gene Products, Human Immunodeficiency Virus / genetics
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env Gene Products, Human Immunodeficiency Virus / immunology*
Substances
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Antibodies, Neutralizing
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HIV Antibodies
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env Gene Products, Human Immunodeficiency Virus
Associated data
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GENBANK/GU455456
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GENBANK/GU455457
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GENBANK/GU455458
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GENBANK/GU455459
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GENBANK/GU455460
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