Abstract
Thirty-one antimicrobial-resistant, extended-spectrum-β-lactamase-producing strains of Vibrio cholerae O1 serotype Ogawa associated with an outbreak of cholera in South Africa (2008) were investigated. Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 β-lactamase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholera / epidemiology*
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Cholera / microbiology*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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DNA, Bacterial / genetics
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Disease Outbreaks*
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Drug Resistance, Multiple, Bacterial*
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Humans
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Polymerase Chain Reaction
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South Africa / epidemiology
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Vibrio cholerae O1 / drug effects
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Vibrio cholerae O1 / enzymology*
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Vibrio cholerae O1 / genetics*
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Vibrio cholerae O1 / isolation & purification
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beta-Lactamases / genetics*
Substances
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DNA, Bacterial
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beta-lactamase TEM-63
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beta-Lactamases
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DNA Topoisomerase IV
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DNA Gyrase