Abstract
1-(2-Deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) has been shown to be a highly effective inhibitor of Simian varicella virus infection in African green monkeys. Administration of FEAU by either intravenous injection or gavage at doses as low as 1 mg/kg/day prevented the development of rash and reduced viremia. The effective dose could be further reduced to 0.2 mg/kg/day when administered in combination with a sub-effective dose of human recombinant interferon-beta. No evidence of toxicity was seen in monkeys treated for 10 days with FEAU doses of 10 mg/kg/day when they were monitored by hematology and clinical chemistry tests and by clinical observations.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenoviridae Infections / prevention & control*
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Adenoviruses, Simian / drug effects
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Animals
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Antiviral Agents / pharmacology*
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Arabinofuranosyluracil / administration & dosage
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Arabinofuranosyluracil / analogs & derivatives*
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Arabinofuranosyluracil / pharmacology
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Chlorocebus aethiops
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Dose-Response Relationship, Drug
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Drug Synergism
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Humans
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Injections, Intravenous
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Interferon Type I / administration & dosage
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Interferon Type I / pharmacology*
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Recombinant Proteins
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Uridine / analogs & derivatives*
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Viremia / drug therapy
Substances
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Antiviral Agents
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Interferon Type I
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Recombinant Proteins
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Arabinofuranosyluracil
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1-(2-deoxy-2-fluoroarabinofuranosyl)-5-ethyluracil
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Uridine