Side effects of radiation in musculoskeletal oncology: clinical evaluation of radiation-induced fractures

Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1 Suppl 2):29-37. doi: 10.1177/03946320110241S207.

Abstract

Radiation therapy and chemotherapy, while they remain an essential part of the multidisciplinary treatment of cancers, they have led to unwanted complications. Radiation-induced complications include wound and bone, growth, nervous system, tumorigenic, lung, gastrointestinal, hepatic and other complications. In this article we review the side effects of radiation therapy in musculoskeletal oncology emphasizing on bone, present our long experience, and discuss the current literature regarding radiation-induced bone complications and their management and outcome.

MeSH terms

  • Adult
  • Aged
  • Bone Nails
  • Bone Neoplasms / complications*
  • Bone Neoplasms / radiotherapy*
  • Bone Neoplasms / secondary
  • Bone and Bones / blood supply
  • Breast Neoplasms / pathology
  • Female
  • Fractures, Bone / diagnostic imaging
  • Fractures, Bone / etiology*
  • Fractures, Bone / pathology
  • Humans
  • Male
  • Middle Aged
  • Muscle Neoplasms / complications*
  • Muscle Neoplasms / radiotherapy*
  • Muscle Neoplasms / secondary
  • Musculoskeletal Diseases / complications*
  • Musculoskeletal Diseases / radiotherapy*
  • Orthopedic Procedures
  • Prosthesis Implantation
  • Radiography
  • Radiotherapy / adverse effects*
  • Regional Blood Flow / radiation effects
  • Young Adult