Abstract
One new drimane-type sesquiterpenoid, 3 β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the whole plant of Polygonum hydropiper Linn. Their structures were determined using spectroscopic techniques. Single-crystal X-ray diffraction study on dendocarbin L (3) and ¹³C-NMR spectroscopic data of (+) winterin (4) are described for the first time. Compound 6 was evaluated for inhibitions of α-chymotrypsin, acetylcholinesterase, and butyrylcholinesterase enzymes.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / drug effects
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Butyrylcholinesterase / drug effects
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Chymotrypsin / antagonists & inhibitors
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Crystallography, X-Ray
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plants, Medicinal / chemistry
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Polycyclic Sesquiterpenes
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Polygonum / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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X-Ray Diffraction
Substances
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3beta-angeloyloxy-7-epifutronolide
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Plant Extracts
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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drimane
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Acetylcholinesterase
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Butyrylcholinesterase
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Chymotrypsin
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alpha-chymotrypsin