Abstract
We describe a 35-year-old man with X-linked agammaglobulinemia who had refractory chronic pleurisy caused by a Helicobacter equorum-like bacterium. Broad-range bacterial PCR targeting the 16S and 23S rRNA genes and in situ hybridization targeting the 16S rRNA gene of H. equorum confirmed the presence of this pathogen in a human for the first time.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Agammaglobulinemia / complications*
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Agammaglobulinemia / diagnosis*
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Chronic Disease
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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Genetic Diseases, X-Linked / complications*
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Genetic Diseases, X-Linked / diagnosis*
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Helicobacter / isolation & purification*
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Helicobacter Infections / diagnosis*
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Helicobacter Infections / microbiology*
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Histocytochemistry
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Humans
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In Situ Hybridization
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Lung / diagnostic imaging
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Lung / pathology
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Male
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Microscopy
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Molecular Sequence Data
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Pleura / pathology
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Pleurisy / diagnosis*
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Pleurisy / microbiology*
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Polymerase Chain Reaction
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RNA, Ribosomal, 16S / genetics
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RNA, Ribosomal, 23S / genetics
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Radiography, Thoracic
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Sequence Analysis, DNA
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Tomography, X-Ray Computed
Substances
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DNA, Bacterial
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DNA, Ribosomal
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RNA, Ribosomal, 16S
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RNA, Ribosomal, 23S
Supplementary concepts
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Bruton type agammaglobulinemia
Associated data
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GENBANK/AB571486
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GENBANK/AB571487