Abstract
3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone), an effective free radical scavenger, provides neuroprotection in stroke models and patients. In this study, we investigated its neuroprotective effects in a chronic rotenone rat model for Parkinson's disease. Here we showed that a five-week treatment with edaravone abolished rotenone's activity to induce catalepsy, damage mitochondria and degenerate dopamine neurons in the midbrain of rotenone-treated rats. This abolishment was attributable at least partly to edaravone's inhibition of rotenone-induced reactive oxygen species production or apoptotic promoter Bax expression and its up-regulation of the vesicular monoamine transporter 2 (VMAT2) expression. Collectively, edaravone may provide novel clinical therapeutics for PD.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antipyrine / analogs & derivatives*
-
Antipyrine / pharmacology
-
Antipyrine / therapeutic use
-
Behavior, Animal / drug effects
-
Dopamine / metabolism*
-
Edaravone
-
Free Radical Scavengers / pharmacology
-
Free Radical Scavengers / therapeutic use*
-
Freezing Reaction, Cataleptic / drug effects
-
Humans
-
Male
-
Neurons / drug effects*
-
Neurons / physiology
-
Neurons / ultrastructure
-
Neuroprotective Agents / pharmacology
-
Neuroprotective Agents / therapeutic use
-
Neuropsychological Tests
-
Parkinsonian Disorders / chemically induced*
-
Parkinsonian Disorders / drug therapy*
-
Parkinsonian Disorders / pathology
-
Parkinsonian Disorders / physiopathology
-
Rats
-
Rats, Wistar
-
Reactive Oxygen Species / metabolism
-
Rotenone / pharmacology*
-
Uncoupling Agents / pharmacology
-
Vesicular Monoamine Transport Proteins / genetics
-
Vesicular Monoamine Transport Proteins / metabolism
-
bcl-2-Associated X Protein / metabolism
Substances
-
Free Radical Scavengers
-
Neuroprotective Agents
-
Reactive Oxygen Species
-
Slc18a2 protein, rat
-
Uncoupling Agents
-
Vesicular Monoamine Transport Proteins
-
bcl-2-Associated X Protein
-
Rotenone
-
Edaravone
-
Antipyrine
-
Dopamine