Abstract
Hypertonic NaHCO3 infusion caused blood volume expansion, increased blood bicarbonate concentration, and delayed the onset of hypophosphatemia in ponies with endotoxemia. However, NaHCO3 infusion did not normalize blood pH, and it increased blood L-lactate concentration, and caused hypokalemia, hypernatremia, and hyperosmolality. The deleterious effects of NaHCO3 infusion in endotoxemia ponies outweighed the beneficial effects. The role of hypertonic NaHCO3 given IV for treatment of endotoxemia in equids must be reevaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bicarbonates / administration & dosage*
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Bicarbonates / blood
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Bicarbonates / pharmacology
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Endotoxins / blood*
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Escherichia coli Infections / blood
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Escherichia coli Infections / chemically induced
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Escherichia coli Infections / veterinary*
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Escherichia coli*
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Female
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Horse Diseases / blood*
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Horse Diseases / chemically induced
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Horses
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Hydrogen-Ion Concentration
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Infusions, Intravenous / veterinary
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Lactates / blood
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Lactic Acid
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Male
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Shock, Septic / blood
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Shock, Septic / chemically induced
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Shock, Septic / veterinary*
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Sodium / administration & dosage*
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Sodium / blood
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Sodium / pharmacology
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Sodium Bicarbonate
Substances
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Bicarbonates
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Endotoxins
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Lactates
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Lactic Acid
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Sodium Bicarbonate
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Sodium