Does it ever make sense to treat a bacterial infection with a drug against which the responsible pathogen possesses a resistance mechanism?

MeSH terms

• Animals
• Anti-Bacterial Agents / pharmacology*
• Anti-Bacterial Agents / therapeutic use*
• Antitubercular Agents / pharmacology*
• Bacterial Proteins / biosynthesis*
• Carbapenems / therapeutic use*
• Drug Resistance, Bacterial*
• Humans
• Klebsiella Infections / drug therapy*
• Klebsiella pneumoniae / drug effects*
• Methicillin-Resistant Staphylococcus aureus / drug effects*
• Mycobacterium tuberculosis / drug effects*
• Staphylococcal Infections / drug therapy*
• Staphylococcus aureus / drug effects*
• beta-Lactamases / biosynthesis*