Primary anaplastic solitary fibrous tumor of the tentorium cerebelli

J Clin Neurosci. 2011 Aug;18(8):1116-8. doi: 10.1016/j.jocn.2010.11.035. Epub 2011 Jun 22.

Abstract

Meningeal solitary fibrous tumors (MSFT) have been described in about 80 patients as benign spindle-cell neoplasms, with few anaplastic variants. We report a 57-year-old male patient with a 4-month history of progressive headache caused by a primary anaplastic MSFT arising from the tentorium cerebelli. MRI revealed a tentorium-based tumor that extended into the occipital lobe superiorly and into the cerebellum inferiorly on the left. Following gross total resection of the tumor and postoperative radiotherapy, the patient experienced symptomatic improvement with no recurrence at the 12-month follow-up. The final tumor pathology was consistent with an anaplastic MSFT, with a Ki-67 proliferative index of 25%.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 12E7 Antigen
  • Antigens, CD / metabolism
  • Antigens, CD34 / metabolism
  • Cell Adhesion Molecules / metabolism
  • Cerebellum / pathology*
  • Dura Mater / pathology*
  • Follow-Up Studies
  • Headache / etiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Solitary Fibrous Tumors / complications
  • Solitary Fibrous Tumors / pathology*
  • Tomography, X-Ray Computed

Substances

  • 12E7 Antigen
  • Antigens, CD
  • Antigens, CD34
  • CD99 protein, human
  • Cell Adhesion Molecules
  • Proto-Oncogene Proteins c-bcl-2