Abstract
The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chemistry. Herein we report the first solid-phase synthesis of a BODIPY library in high purities. We screened the library against a set of proteins, identified an immunoglobulin fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boron Compounds / chemical synthesis
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Boron Compounds / chemistry*
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Electron Spin Resonance Spectroscopy
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Humans
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Immunoglobulin G / analysis*
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Protein Binding
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Spectrometry, Fluorescence / methods*
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Fluorescent Dyes
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Immunoglobulin G