Expression and function of fatty acid-binding protein 4 during mouse decidualization

Fertil Steril. 2011 Jun 30;95(8):2749-52.e1-5. doi: 10.1016/j.fertnstert.2011.05.052.

Abstract

Fatty acid-binding protein 4 (Fabp4) is highly expressed in the secondary decidual zone of mouse decidua and deciduoma and stromal cells under in vitro decidualization. Dtprp, a well-known marker of in vitro decidualization, is diminished by small interfering RNA against Fabp4 and FABP4 inhibitor and stimulated through Fabp4 overexpression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biphenyl Compounds / pharmacology
  • Cells, Cultured
  • Decidua / drug effects
  • Decidua / metabolism*
  • Deciduoma / metabolism
  • Embryo Implantation* / drug effects
  • Embryo Implantation* / genetics
  • Estradiol / metabolism
  • Fatty Acid-Binding Proteins / antagonists & inhibitors
  • Fatty Acid-Binding Proteins / genetics
  • Fatty Acid-Binding Proteins / metabolism*
  • Female
  • Gene Expression Regulation
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Mice
  • Pregnancy
  • Progesterone / metabolism
  • Prolactin / analogs & derivatives
  • Prolactin / metabolism
  • Pyrazoles / pharmacology
  • RNA Interference
  • RNA, Messenger / metabolism
  • Stromal Cells / metabolism
  • Time Factors
  • Transfection

Substances

  • 2-(2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy)acetic acid
  • Biphenyl Compounds
  • Dtprp protein, mouse
  • FABP4 protein, human
  • Fabp4 protein, mouse
  • Fatty Acid-Binding Proteins
  • Pyrazoles
  • RNA, Messenger
  • Progesterone
  • Estradiol
  • Prolactin