Use of an automated ACTH assay for the diagnosis of pituitary and adrenal-related diseases

J Brossaud; M Bouton; B Gatta; A Tabarin; J-B Corcuff

doi:10.1016/j.clinbiochem.2011.06.002

Use of an automated ACTH assay for the diagnosis of pituitary and adrenal-related diseases

Clin Biochem. 2011 Sep;44(13):1160-1162. doi: 10.1016/j.clinbiochem.2011.06.002. Epub 2011 Jun 17.

Authors

J Brossaud¹, M Bouton¹, B Gatta², A Tabarin², J-B Corcuff³

Affiliations

¹ Department of Nuclear Medicine, University Hospital, Bordeaux, France.
² Department of Endocrinology, University Hospital, Bordeaux, France.
³ Department of Nuclear Medicine, University Hospital, Bordeaux, France. Electronic address: [email protected].

PMID: 21704612
DOI: 10.1016/j.clinbiochem.2011.06.002

Abstract

Objective: To evaluate Liaison Diasorin's automated ACTH assay.

Design: We investigated the limit of quantification (LOQ) and simulated the usage of the analyzer using our ACTH results database.

Results: The LOQ was close to the cut-off determining Cushing's syndrome ACTH dependency. 25% concentrations of normal subjects were lower than the LOQ. Although biased, the results were concordant with those of an IRMA assay.

Conclusion: This assay is not sensitive enough to diagnose ACTH-independent Cushing's syndrome.

Publication types

Evaluation Study

MeSH terms

Adrenal Gland Diseases / diagnosis*
Adrenocorticotropic Hormone / analysis*
Cushing Syndrome / diagnosis
Diagnostic Techniques and Procedures / standards*
Humans
Limit of Detection
Pituitary Diseases / diagnosis*
Sensitivity and Specificity

Substances

Adrenocorticotropic Hormone