Bioengineering RNA silencing across the life kingdoms

Recent Pat Biotechnol. 2011 Aug;5(2):118-46. doi: 10.2174/187220811796365680.

Abstract

RNA silencing negatively regulates gene expression at transcriptional and posttranscriptional levels, guided by small RNA molecules. It modulates core regulatory pathways across the eukaryotes, such as developmental processes or stress responses. The widespread existence of this phenomenon and the key pathways regulated have led to the development of a new technology based on the modification of gene expression, which has been applied successfully in different areas such as medicine or agriculture. Here we review the most important patents related to RNA silencing across the life kingdoms, including biotechnological applications into medicine, crop science and bioengineering.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomedical Engineering / methods*
  • Fungi / drug effects
  • Fungi / genetics
  • Fungi / metabolism
  • Gene Expression Regulation, Neoplastic / drug effects
  • Gene Expression Regulation, Plant / drug effects
  • Gene Expression Regulation, Viral / drug effects
  • Genetic Therapy / methods*
  • Herpesviridae Infections / drug therapy
  • Herpesviridae Infections / pathology
  • Herpesviridae Infections / virology
  • Herpesvirus 8, Human / drug effects
  • Herpesvirus 8, Human / growth & development
  • Humans
  • MicroRNAs / genetics
  • Oligonucleotides, Antisense / pharmacology*
  • Oligonucleotides, Antisense / therapeutic use
  • Parainfluenza Virus 1, Human / drug effects
  • Parainfluenza Virus 1, Human / growth & development
  • Paramyxoviridae Infections / drug therapy
  • Paramyxoviridae Infections / pathology
  • Paramyxoviridae Infections / virology
  • Patents as Topic
  • Plants / drug effects
  • Plants / genetics
  • Plants / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • RNA Interference / drug effects*
  • RNA, Small Interfering / pharmacology*
  • RNA, Small Interfering / therapeutic use
  • Respiratory Syncytial Virus Infections / drug therapy
  • Respiratory Syncytial Virus Infections / pathology
  • Respiratory Syncytial Virus Infections / virology
  • Respiratory Syncytial Viruses / drug effects
  • Respiratory Syncytial Viruses / growth & development

Substances

  • MicroRNAs
  • Oligonucleotides, Antisense
  • RNA, Small Interfering