Abstract
Both symmetric and asymmetric divisions rely on alignment of the mitotic spindle with cues from the environment. A study now shows that mitotic spindles find their position by reading the map of forces that load-bearing retraction fibres exert on the cell body.
MeSH terms
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Actins / metabolism
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Animals
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Cell Adhesion*
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Cell Polarity
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Cell Shape
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Fibronectins / metabolism
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Homeostasis
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Humans
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Mechanotransduction, Cellular*
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Mitosis*
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Morphogenesis
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Rotation
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Spindle Apparatus / metabolism
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Spindle Apparatus / physiology*
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Stress, Mechanical