The mammalian target of rapamycin (mTOR) integrates signalling responses to growth factors and nutrients. The macrolide rapamycin inhibits mTOR function and has been used extensively to demonstrate a critical role for mTOR in immune responses. This mini-review summarizes recent evidence demonstrating an integral role for mTOR in the differentiation of T helper cell subsets and the development, maturation and antigen-presenting capacity of DCs in both mice and humans.
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