Wnt to notch relay signaling induces definitive hematopoiesis

Dirk Loeffler; Konstantinos D Kokkaliaris; Timm Schroeder

doi:10.1016/j.stem.2011.06.011

Wnt to notch relay signaling induces definitive hematopoiesis

Cell Stem Cell. 2011 Jul 8;9(1):2-4. doi: 10.1016/j.stem.2011.06.011.

Authors

Dirk Loeffler, Konstantinos D Kokkaliaris, Timm Schroeder

PMID: 21726826
DOI: 10.1016/j.stem.2011.06.011

Abstract

The molecular mechanisms specifying hematopoietic stem cells (HSCs) in the vertebrate embryo remain poorly understood. Recently in Nature, Traver and colleagues demonstrate that timed wnt to Notch relay signaling across multiple cell types serves as an early upstream mechanism of HSC induction in zebrafish (Clements et al., 2011).