Hetero-Diels-Alder reaction of phosphinyl and phosphonyl nitroso alkenes with conjugated dienes: an aza-Cope rearrangement

J Org Chem. 2011 Aug 19;76(16):6715-25. doi: 10.1021/jo201116u. Epub 2011 Jul 15.

Abstract

Phosphorylated nitroso alkenes react with cyclic dienes such as cyclopentadiene or cyclohexadiene to afford hetero Diels-Alder-type cycloadducts where the nitroso alkene participates as dienophile component and the cyclic olefin acts as the 4π-electron (diene) system. Subsequent aza-Cope rearrangement affords highly functionalized 5,6-dihydro-4H-1,2-oxazines. Conversely, the reaction of TMS-substituted cyclopentadiene (dienophile) with nitroso alkenes as heterodienes leads directly to bicyclic 1,2-oxazines. Theoretical studies are in agreement with the experimental results and with the new aza-Cope rearrangement proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Molecular Structure
  • Nitroso Compounds / chemistry*
  • Organophosphorus Compounds / chemistry*
  • Phosphines / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Nitroso Compounds
  • Organophosphorus Compounds
  • Phosphines