Aim: To investigate whether this might be related to the presence of hyperhomocysteinemia.
Methods: From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease (CD) patients (138 females and 27 males, mean age 43 years).
Results: Hyperhomocysteinemia was evident in 32 patients (19.3%), although most of them had moderate levels (mean value 25 mcg/ml; range 15-30). Only one patient had a history of myocardial infarction (heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).
Conclusion: The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients.
Keywords: Celiac disease; Endoscopy; Histology; Hyperhomocysteinemia.