Abstract
Hypertrophic osteoarthropathy (HOA) is the classical neoplastic disease in rheumatology characterized by a combination of digital clubbing, joint and bone pain, and proliferative periostitis. This combination of symptoms should initiate an intensive search for an underlying malignant disease usually of thoracic organs. Here we report the case of a patient with HOA and neuroendocrine carcinoma of the esophagus. Other non-malignant disorders of the lungs, heart and other organs should be considered in the differential diagnosis. In addition, rare cases of a primary hereditary form of HOA exist and the genetic background has recently been discovered. Thus, new insights into the pathophysiology have improved diagnostic and therapeutic options for this disorder.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Adult
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Cardia* / pathology
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Cooperative Behavior
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Diagnosis, Differential
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Early Diagnosis
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Esophageal Neoplasms / diagnosis*
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Esophageal Neoplasms / pathology
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Fluorodeoxyglucose F18
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Gastroscopy
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Humans
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Interdisciplinary Communication
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Male
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Multimodal Imaging
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Neoplasm Invasiveness
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Neuroendocrine Tumors / diagnosis*
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Neuroendocrine Tumors / pathology
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Osteoarthropathy, Secondary Hypertrophic / diagnosis*
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Osteoarthropathy, Secondary Hypertrophic / etiology
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Osteoarthropathy, Secondary Hypertrophic / pathology
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Paraneoplastic Syndromes / diagnosis*
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Paraneoplastic Syndromes / etiology
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Paraneoplastic Syndromes / pathology
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Positron-Emission Tomography
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Prognosis
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Risk Factors
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Stomach Neoplasms / diagnosis*
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Stomach Neoplasms / pathology
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Tomography, X-Ray Computed